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CD/T 7 Way and 8 Way comparison and Information

Amber Waves Pygmy Goats Metal Elastrator

Posted by GoatWorld on June 15, 2002 at 11:51:01:

Hi folks,

Something that seems confusing to some (at least to me) is the difference between the CD/T 7 Way and CD/T 8 Way vaccination recommended to be given at 30 days of age and boostered yearly. Hopefully this will put things in perspective.

CD/T 8 Way - known as "Covexin 8" - at least in the case of this particular manufacturer (Schering-Plough) vaccinates against the following:

Clostridium chauvoei (also called Clostridium feseri)
Clostridium septicum

Clostridium novyi Type B (called Clostridium oedematiens by the British)

Clostridium haemolyticum (also known as Clostridium novyii or oedematiens type D)

Clostridium tetani
Clostridium perfringens Type C (also known as Clostridium welchii)
Clostridium perfringens Type D (also known as Clostridium welchii)

The label goes on to state:
"Although Clostridium perfringens Type B is not considered a significant problem in the U.S.A., immunity may be provided against the beta and epsilon toxins elaborated by Clostridium perfringens Type B. This immunity is derived from the combination of Type C (beta) and Type D (epsilon) fractions."


CD/T 7 Way -

Clostridium chauvoei (also called Clostridium feseri)
Clostridium septicum
Clostrium sordelli (also known as Clostridium bifermentans c)
Clostridium novyi
Clostridium perfringens Type C
Clostridium perfringens Type D


The label goes on to state:
"Although Clostridium perfringens Type B is not considered a significant problem in the U.S.A., immunity may be provided against the beta and epsilon toxins elaborated by Clostridium perfringens Type B. This immunity is derived from the combination of Type C (beta) and Type D (epsilon) fractions."


So what does all this mean? Basically that the Covexin 8 is providing one more vaccination than the Bar-Vac 7. However, you'll notice that Bar-Vac 7 includes "Clostridium sordelli" where Covexin 8 does not. On the other hand, Covexin 8 vaccinates against the bacteria "Clostridium haemolyticum and Clostridium tetani".

Description of each bacteria in easy to understand terms:
Clostridium chauvoei produces blackleg in cattle, sheep and other ungulates.

Clostridium tetani Tetanus results from trauma or a puncture wound leading to tissue contamination.

Clostridium septicum has been strongly associated with an underlying malignancy (Malignant Edema). That is, 83% of (human) patients having a C. septicum infection have also been diagnosed with cancer.

Clostridium Perfringens Type B, C & D Enterotoxemia

Clostridium Novyi Black Disease

Clostridium sordelli Sord

Clostridial Diseases
CLOSTRIDIA are a large group of common bacterial organisms. These bacteria, as resistant spores, live for long periods of time in the soil and are passed to a susceptible animal from soil or vegetation either through a wound or by ingestion. Such diseases as Botulism and Tetanus (lockjaw) are clostridial diseases, but are generally vaccinated against only in specific instances in cattle.

Blackleg is a general term used by many producers to describe clostridial diseases. However, this is technically incorrect and there are specifically recognized diseases. Blackleg is characterized by lameness, swelling and a dark red to black discoloration of the heavy, active muscle tissues. In late stages, there will be gas production which will accumulate in all muscle areas and subcutaneously. Malignant Edema resembles Blackleg, as there will be gaseous swelling of affected muscles, which become gangrenous as infected tissue dies. Black Disease is often characterized by black lesions in the muscles of the throat and brisket, while SORDELLII affects muscles of the throat and brisket as well as many other muscles. With SORD, marked yellow gelatinous swellings will often be seen between muscle layers. Redwater is characterized by severe depression, abdominal pain and labored breathing. Animals infected with enterotoxemias exhibit signs ranging from abdominal pain and diarrhea to convulsions and blindness.

High fever is a characteristic of all clostridial infections. Onset and progression of these diseases are rapid and many animals die before signs are noticed. In fact, sudden death is a common feature of all these clostridial diseases. Unless observed very early in the course of the disease, antibiotics are generally of little value and death rates approach 100% in spite of attempts at treatment.

The "7-way" vaccine protects against Blackleg and Blackleg-type diseases, as well as Enterotoxemia. The organisms involved are:

Blackleg - CLOSTRIDIUM CHAUVOEI
Malignant Edema - CLOSTRIDIUM SEPTICUM
Black Disease - CLOSTRIDIUM NOVYI
Sord - CLOSTRIDIUM SORDELLII
Enterotoxemia - CLOSTRIDIUM PERFRINGENS TYPE B, C AND D.
The "4-way" vaccine contains CL. CHAUVOEI, CL. SEPTICUM, CL. NOVYI, AND CL. SORDELLII and not the CLOSTRIDIA causing enterotoxemia. Other combinations may include only a portion of these CLOSTRIDIA and some also include CLOSTRIDIUM HAEMOLYTICUM (Redwater).

Animals 5 to 15 months of age are generally the most susceptible, with younger animals generally protected by passive immunity acquired from colostrum ingested at nursing. The disease is seldom contracted by animals over 3 years of age. Caution: In some herds (areas), the bacteria spores are so concentrated that animals only 2 or 3 months old, as well as mature animals, are infected. Current recommendations are for vaccination at 3 months (cattle) of age and again at weaning. In some cases, annual re-vaccination of the entire herd is required. Generally, vaccination with "7-way" vaccine is the most cost-effective route for disease prevention.

For those who know and understand virology, there is an excellent information contained on each of these bacterins located at:
http://vtpb-www.cvm.tamu.edu/vtpb/vet_micro/descriptions_bacteria/gram_pos_spore.shtml

Hope this helps everyone get a better understanding of the use of CD/T vaccinations and the differences between the two.

Best regards,

Gary


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